Evaluation of anti-diabetic activity of Justicia adhatoda (Linn.) Leaves in diabetic wistar rats

INTRODUCTION Diabetes mellitus is defined as the increase in blood glucose level resulting from defects insulin secretion, action, or both. The present study was conducted to evaluate anti-diabetic activity of Justicia adhatoda (Linn.) leaves extract diabetic Wistar rats. adhatoda, commonly known vasaka rich phytochemicals like alkaloids, saponins, steroids, flavonoids and glycosides. It used asthma, jaundice, wound healing, typhus fever, cough, chronic bronchitis inflamma- tory swellings treatment. MATERIAL AND METHODS obtained by maceration process with use methanol solvent. 30 rats 150-250 gm were taken animal. induced single intraperitoneal injection Alloxan 150 mg/kg body weight. methan- olic low dose (50 mg/kg) high (100 given orally for activity. standard drug glimepiride 0.5 weight used. RESULTS treated 50mg/kg 100mg/kg showed significant p<0.01 reduction while less p<0.05. p<0.05 recovery compar- ison negative control group. 50 mg/kg, 100 improvement food intake when compared treatment p<0.01, highly p<0.001 water on 1st, 2nd 3rd week respectively CONCLUSION concludes that possesses potent leaves.